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ea0029oc6.3 | Female Reproductioin Basic | ICEECE2012

LH and hCG produce different responses in human granulosa lutein cells in vitro

Casarini L. , Pignatti E. , La Marca A. , Marsella T. , Tagliasacchi D. , Adversi F. , Lispi M. , Longobardi S. , Simoni M.

Introduction: LH and hCG act on the same receptor (LHCGR), but it is not known whether they elicit the same cellular and molecular response. This study aims at comparing the activation of cell-signalling pathways and gene expression in response to LH and hCG.Design: We evaluated the activation of cAMP, ERK and AKT-pathways and progesterone production by ELISA and Western blotting in human primary granulosa cells (hGLC) stimulated for up to 36 hours with ...

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ea0029p1755 | Thyroid cancer | ICEECE2012

The TRHR gene is associated to hypothalamo-pituitary sensitivity to levothyroxine in thyroidectomized patients

Brigante G , Spaggiari G , Cioni K , Gnarini V , Pignatti E , Casarini L , Marino M , Tuttelmann F , Carani C , Simoni M

Background: Patients thyroidectomized for thyroid cancer need variable doses of levothyroxine (LT4) to obtain TSH suppression. A predetermined thyroid function set-point for each individual has been hypothesized, suggesting a genetic influence in the regulation of pituitary-thyroid axis. We hypothesized of the TRHR gene could be associated with a different hypothalamo-pituitary sensitivity to the negative feedback of the thyroid hormones.<p class=...

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Endocrine Abstracts

LH and hCG produce different responses in human granulosa lutein cells in vitro

The TRHR gene is associated to hypothalamo-pituitary sensitivity to levothyroxine in thyroidectomized patients

BiosciAbstracts